11-Deoxycorticosterone

11-Deoxycorticosterone

11-Deoxycorticosterone

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Description:
11-Deoxycorticosterone (or deoxycorticosterone or 21-hydroxyprogesterone) is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone. As its names indicate, it can be understood as 21-hydroxy- variant of progesterone or a 11-deoxy- variant of corticosterone. It has no significant glucocorticoid activity.

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<gallery>File:Steroidogenesis.svg|SteroidogenesisFile:Corticosterone-2D-skeletal.svg|Corticosterone</gallery>

Deoxycorticosterone physiology

11-Deoxycorticosterone is a precursor molecule for the production of aldosterone. The major pathway for aldosterone production is in the adrenal glomerulosa zone of the adrenal gland. It is not a major secretory hormone. It is produced from progesterone by 21β-hydroxylase and is converted to corticosterone by 11β-hydroxylase. Corticosterone is then converted to aldosterone by aldosterone synthase. Mark's Basic Medical Biochemistry: A Clinical Approach

Most of the deoxycorticosterone (also called cortexone, 11 desoxycorticosterone, deoxycortone, desoxycortone, compound B, DOC) is secreted by the zona fasiculata of the adrenal cortex which also secretes cortisol, and a small amount by the zona glomerulosa, which secretes aldosterone. DOC stimulates the collecting tubules (the tubules which branch together to feed the bladder) <ref...
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