January 2, 2001: Charlie Hayes was signed as a Free Agent with the Houston Astros.
January 3, 2001: Kent Bottenfield was signed as a Free Agent with the Houston Astros.
June 8, 2001 - The first interleague game between the Houston Astros and the Texas Rangers took place at The Ballpark at Arlington. The rivalry would be known as the Lone Star Series. The Astros won the game by a score of 5-4. The team that would win the most games between the two in a season would be awarded the Silver Boot.
October 4, 2001: Barry Bonds hits his 70th Home Run of the season off Houston pitcher Wilfredo Rodriguez, to tie Mark McGwire’s single season home run record.
June 5, 2001: Kirk Saarloos was drafted by the Houston Astros in the 3rd round of the 2001 amateur draft. Player signed June 24, 2001.