The name 5th Avenue refers to the 5th Avenue of Reading, Pennsylvania where the candy bar was originally produced.
World War II forced Luden’s to concentrate production efforts on Luden's menthol throat drops and 5th Avenue bars for military use. Immediately following the war, Luden's reverted to producing a full line of confectionery products.
The candy bar previously sported two thick chocolate-coated almond halves on top. This was discontinued when Hershey's acquired Luden's in 1987, keeping the 5th Avenue bar but eventually selling Luden's cough drops.