Adventures of Frank and Jesse James was budgeted at $149,985 although the final negative cost was $149,805 (a $180, or 0.1%, under spend). It was the cheapest Republic serial of 1948, despite having one more chapter than the other two serials.
It was filmed between 5 April and 26 April 1948.
This was the fourth of only four 13-chapter serials to be released by Republic. The previous three were released in 1947, the only original serials released in that year.
Adventures of Frank and Jesse James' official release date is 30 October 1948, although this is actually the date the sixth chapter was made available to film exchanges.