Andrew Stetson worked as a carpenter before becoming a fashion model at the age of 19. He was discovered by Norwayne Anderson of the NAM agency.
After a year of modeling in New York and Europe, he returned to renovating homes and started a home renovation business, although his friends and family would later encourage him to return to modeling. He has since walked for many designers and has appeared in numerous ad campaigns for Armani, Chanel, Dolce & Gabbana, Zara, Calvin Klein, Levi's, Bloomingdales, and H&M. He also made the cover of gay French Magazine Tetu in 2005. On August 2006, Stetson had signed a three-year contract for Calvin Klein's fragrance, Euphoria. He was succeeded by Carson Parker as the face of Euphoria and Garrett Neff as the spokesmodel for the company..
March 19, 2011 Andrew Stetson married his girlfriend Stine in Denmark.