In former times it was used medically by North American Indigenous peoples as an astringent and as a styptic for wounds, sores, nosebleeds, and as an eyewash. The root was respected by Plains tribes and used for many ailments.
It is likely that most Anemones contain the caustic irritants of the Ranunculaceae family. Foster, Steven and James A. Duke. Eastern/Central Medicinal Plants, "Peterson Field Guides", Houghton, Mifflin 1990 edn. ISBN 0-395-92066-3