Floro Flores was born in Naples, and started his career at Napoli. He made his Serie A debut on 28 January 2001 against Roma. After six months on loan to Serie A Sampdoria, Floro Flores transferred to Perugia after the club had gone bankrupt. At Perugia, Floro Flores scored 8 goals in Serie B, and two more against Treviso in the promotion play-off second legs. But Perugia also faced bankruptcy, and Floro Flores joined Arezzo in the summer of 2005.
After Arezzo got relegated to Serie C1 on summer 2007, he was signed by Udinese Calcio, by buying the player's other half registration rights.