Antonio Nocerino was born in Naples on the 9 April 1985 to Ciro and Giovanna.
He started his career at Juventus and, after a loan spell at U.S. Avellino, Genoa bought him in a co-ownership deal, as part of Domenico Criscito and Francesco Volpe went to Turin. He was priced €450,000 for half of his rights. He was bought back in summer 2006 to prepare for Juventus first Serie B campaign, but soon sold to Piacenza in July for undisclosed fees.
In July 2007 Juventus, who held 50% of the player's rights, bought the remainder from Piacenza, for €3.7M. He was transferred from Juventus to Palermo in a transfer package deal for Amauri for the 08/09 season which Nocerino was priced €7.5M. Despite some initial difficulties, he has now become an integral part of the Palermo's midfield.