B-cell receptor

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The B-cell receptor is a transmembrane receptor protein located on the outer surface of B-cells. The receptor's binding moiety is composed of a membrane-bound antibody that, like all antibodies, has a unique and randomly-determined antigen-binding site. When a B-cell is activated by its first encounter with an antigen that binds to its receptor (its "cognate antigen"), the cell proliferates and differentiates to generate a population of antibody-secreting plasma B cells and memory B cells.

Components of the B-cell receptor

The B-cell receptor is composed of two parts:
  1. Ligand binding moiety: A membrane-bound bound immunoglobulin molecule of one isotype (IgD, IgM, IgE or IgE). With the exception of the presence of an integral membrane domain, these are identical to their secreted forms.
  2. Signal transduction moiety: A heterodimer called Ig-α/Ig-β (CD79), bound together by disulfide bridges. Each member of the dimer spans the plasma membrane and has a cytoplasmic tail bearing an immunoreceptor tyrosine-based activation motif .


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