Basement membrane

Basement Membrane

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Basement membrane

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The basement membrane is a thin sheet of fibers that underlies the epithelium, which lines the cavities and surfaces of organs including skin, or the endothelium, which lines the interior surface of blood vessels.


The basement membrane is the fusion of two lamina, the basal lamina and the reticular lamina (or lamina reticularis). The lamina reticularis is attached to the basal lamina with anchoring fibrils (type VII collagen fibers) and microfibrils (fibrillin). The two layers are collectively known as the basement membrane. M Paulsson; ; Critical Reviews in Biochemistry and Molecular Biology, Vol 27, Issue 1, 93-127, 1992

The basal lamina layer can further be divided into two layers. The clear layer closer to the epithelium is called the lamina lucida, while the dense layer closer to the connective tissue is called the lamina densa. The electron-dense lamina densa membrane is about 30–70 nanometers in thickness, and consists of an underlying network of reticular collagen (type IV) fibrils (fibroblast precursors) which average 30 nanometers in diameter and 0.1–2 micrometer in thickness. This type III collagen is of the reticular type, in contrast to the fibrillar collagen found in the interstitial matrix. Kumar, Abbas, Fausto; Robbins and Cotran: Pathologic Basis of Disease; Elsevier, 7th ed. Stanley JR, Woodley DT, Katz SI, Martin GR; ; J Invest......
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