Most of Yuzna's film work is in the horror genre, though he has also ventured into science fiction. Like his friend and fellow filmmaker Stuart Gordon, Yuzna is a big fan of H. P. Lovecraft and has adapted several Lovecraft stories for the screen.
With Julio Fernández, Yuzna started Fantastic Factory, a label under Barcelona film company Filmax. Yuzna's goal for Fantastic Factory is produce "modestly budgeted genre (horror, science fiction, fantasy) films for the international market (shot in English language) using genre talent from all around the world and to develop local talent." He was last working as the producer of the Wehrmacht zombie movie Worst Case Scenario, directed by Richard Raaphorst, which takes place after a fictional World Cup 2006 Finale between Germany and Netherlands where Germany loses and seeks revenge with a zombie invasion, in May 2009 was announced the project is dead. After four years returned to the Director's chair and filmed the movie Amphibious 3-D who is starring Michael Paré, Janna Fassaert and Francis Magee.