CCL2

For the ICAO airport code see Candle Lake Airpark, for the diradical compound see Dichlorocarbene.

Chemokine (C-C motif) ligand 2 (CCL2) is a small cytokine belonging to the CC chemokine family that is also known as monocyte chemotactic protein-1 (MCP-1) and small inducible cytokine A2. CCL2 recruits monocytes, memory T cells, and dendritic cells to sites of tissue injury, infection, and inflammation.

Genomics

As with many other CC chemokines, CCL2 is located on chromosome 17 (17q11.2-q21.1) in humans.The gene spans 1,927 bases and lies on the Watson (plus) strand. The gene has three exons and two introns. It is produced as a protein precursor containing signal peptide of 23 amino acids and a mature peptide of 76 amino acids. The predicted weight is 11.025 kiloDaltons (kDa).

In the mouse the homolog is Sig-je.

Population genetics

The levels of this protein vary considerably between normal people. Multivariable-adjusted heritability of CCL2 concentrations in whites of European descent has been reported to be 0.37 in plasma and 0.44 in serum

Molecular biology

It is a monomeric polypeptide, with a molecular......
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