As with many other CC chemokines, CCL2 is located on chromosome 17 (17q11.2-q21.1) in humans.The gene spans 1,927 bases and lies on the Watson (plus) strand. The gene has three exons and two introns. It is produced as a protein precursor containing signal peptide of 23 amino acids and a mature peptide of 76 amino acids. The predicted weight is 11.025 kiloDaltons (kDa).
In the mouse the homolog is Sig-je.
The levels of this protein vary considerably between normal people. Multivariable-adjusted heritability of CCL2 concentrations in whites of European descent has been reported to be 0.37 in plasma and 0.44 in serum