Co-amilozide

Co-amilozide (BAN) is a non-proprietary name used to denote a combination of amiloride and hydrochlorothiazide. Co-amilozide is used in the treatment of hypertension and congestive heart failure with the tendency of the thiazide to cause low potassium levels (hypokalaemia) offset by the potassium-sparing effects of amiloride.

Formulation

Two strengths of co-amilozide are currently available in the UK:British National Formulary 54 September 2007

• 2.5 mg amiloride and 25 mg hydrochlorothiazide, BAN of Co-amilozide 2.5/25 (brand name Moduretic 25)
• 5 mg amiloride and 50 mg hydrochlorothiazide, BAN of Co-amilozide 5/50 (brand name Moduretic)

Side effects

The most common side effect is headache (about 8% of people taking it) and nausea, loss of appetite, weakness, rash and dizziness (each about 3%).

Common side effects (1/10 - 1/100) include:

• General: Weakness, fatigue, loss of appetite. Headache, dizziness.
• Circulatory system: Arrhythmia.
• Gastrointestinal: Nausea, diarrhea, abdominal pain.
• Skin: Exanthema, itching.
• Respiratory system: dyspnoea, cough.
• Metabolic.: Hyperglycemia in diabetic patients, hyperuricemia.
• Musculoskeletal.: Pain in the limbs.

References

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