Cre-Lox recombination

Cre-Lox Recombination

Cre-Lox recombination

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Cre-Lox recombination is a special type of site-specific recombination developed by Dr. Brian Sauer initially for use in activating gene expression in mammalian cell lines and transgenic mice (DuPont).Sauer, B. (1987) "Functional expression of the Cre-Lox site-specific recombination system in the yeast Saccharomyces cerevisiae", Mol Cell Biol 7: 2087-2096Sauer, B. and Henderson, N. (1988) "Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1." Proc. Natl. Acad. Sci. USA, 85: 5166-5170. Shortly thereafter, the laboratory of Dr. Klaus Rajewsky reported the production of pluripotent embryonic stem cells bearing a targeted loxP-flanked (floxed)...
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