Adapter molecule crk
also known as proto-oncogene c-Crk
is a protein
that in humans is encoded by the CRK gene
Adapter molecule crk is a member of an adapter protein
family that binds to several tyrosine-phosphorylated proteins. This protein has several SH2
domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase
through SH2-phosphotyrosine interaction. The N-terminal
SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal
SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
Crk together with CrkL
participates in the Reelin
signaling cascade downstream of DAB1
v-Crk, a transforming oncoprotein from avian sarcoma viruses, is a fusion of viral "gag" protein with the SH2 and SH3 domains of cellular Crk.
Crk should not be confused with Src
, which also has cellular (c-Src) and viral (v-Src) forms and is involved in some of the same signaling pathways but is a protein tyrosine-kinase.
CRK (gene) has been shown to interact
,<ref... Read More