DCTP deaminase (dUMP-forming)

DCTP Deaminase (DUMP-Forming)

DCTP deaminase (dUMP-forming)

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In enzymology, a dCTP deaminase (dUMP-forming) () is an enzyme that catalyzes the chemical reaction

dCTP + 2 H<sub>2</sub>O <math>rightleftharpoons</math> dUMP + diphosphate + NH<sub>3</sub>

Thus, the two substrates of this enzyme are dCTP and H<sub>2</sub>O, whereas its 3 products are dUMP, diphosphate, and NH<sub>3</sub>.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is dCTP aminohydrolase (dUMP-forming). This enzyme participates in pyrimidine metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes , , and .


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