Deleted in Liver Cancer 1
also known as DLC1
and StAR-related lipid transfer protein 12 (STARD12) is a protein
which in humans is encoded by the DLC1 gene
This gene is deleted in the primary tumor of hepatocellular carcinoma
. It maps to 8p22-p21.3, a region frequently deleted in solid tumors. It is suggested that this gene is a candidate tumor suppressor gene
for human liver cancer, as well as for prostate, lung, colorectal, and breast cancers.
The human DLC1
gene is located on the short arm of chromosome 8 (8p21.3-22), within a region that frequently undergoes loss of heterozygosity
by either genomic deletion or epigenetic silencing
mechanisms in several types of solid cancers. The gene contains 14 exons
and produces an mRNA
transcript that is 6.3 kb in length; the second AUG present in the open reading frame is the major translational start site, and produces a polypeptide which is 1091 amino acids long.
The promoter region of the DLC1
gene contains a CpG island containing several CpG sites which can be methylated to promote gene silencing and prevent transcription.DLC1
is frequently inactivated in human hepatocellular carcinoma, as well as some nasopharyngeal, lung, breast, prostate, kidney, colon, uterine, ovarian, and... Read More