Governor Crespo faced a critical economic situation. His administration controlled spending and paid off debt, bringing order to the provincial budget. Crespo sponsored laws favouring the rent of public lands and encouraging immigration and colonization, and organized a more independent judicial branch.
Crespo was Santa Fe's representative at the meeting summoned in April 1852 by Urquiza in San Nicolás de los Arroyos in order to agree on the preliminary steps towards the creation of the National Constitution. The San Nicolás Agreement designed the city of Santa Fe as the seat of the General Constitutional Congress, which was held there in 1853.