DTDP-4-dehydrorhamnose reductase

DTDP-4-Dehydrorhamnose Reductase

DTDP-4-dehydrorhamnose reductase

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Description:
In enzymology, a dTDP-4-dehydrorhamnose reductase () is an enzyme that catalyzes the chemical reaction

dTDP-6-deoxy-L-mannose + NADP<sup>+</sup> <math>rightleftharpoons</math> dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H<sup>+</sup>


Thus, the two substrates of this enzyme are dTDP-6-deoxy-L-mannose and NADP<sup>+</sup>, whereas its 3 products are dTDP-4-dehydro-6-deoxy-L-mannose, NADPH, and H<sup>+</sup>.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is dTDP-6-deoxy-L-mannose:NADP+ 4-oxidoreductase. Other names in common use include dTDP-4-keto-L-rhamnose reductase, reductase, thymidine diphospho-4-ketorhamnose, dTDP-4-ketorhamnose reductase, TDP-4-keto-rhamnose reductase, and thymidine diphospho-4-ketorhamnose reductase. This enzyme participates in 3 metabolic pathways: nucleotide sugars metabolism, streptomycin biosynthesis, and polyketide sugar unit biosynthesis.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes , , , , and .

References








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