Dwayne is a boys name. It is Gaelic in origin and comes from the name Dubhan.
St. Dubhan was a Welsh monk who established an abbey in Hook Head Ireland during the 5th century. As a surname it is O'Dubhain, or Dubhan. Dubhain was a popular given name in 16th century southern Ireland. Anglicized form is Duane. In Gaelic "dubh" means "little dark one".