The song was #1 on the BillboardHot Mainstream Rock Tracks chart for 11 consecutive weeks and #2 on the BillboardHot Modern Rock Tracks chart for a single week. It also hit #67 on the Billboard Hot 100. The band performed the song during their performance at Live 8; its performance is the only one of the three songs they played there that appears on the concert DVD.
The song's music video strongly follows the meaning of the song, showing Weiland struggling to maintain his relationship with his wife (who appears in the video as herself). The video shows a graphic depiction of Scott going through an overdose, but being "rescued" by bassist Duff McKagan.