Flo is on her way to Houston, Texas for a new job as a restaurant hostess (as described in her last appearance in Alice) when she stops to visit her family in her hometown of Fort Worth, which she refers to as "Cowtown", as do many real-life locals. In a fit of nostalgia, she buys a rundown roadhouse she had enjoyed in her formative years, and names it "Flo's Yellow Rose". Coping with the business, as well as her mother and sister, caused most of the conflict in the series.
Vic Tayback made one appearance as Mel Sharples from Alice. Once Flo began, Polly Holliday never appeared again on Alice, except in flashback clips in the last episode.