County Road 15 in Osceola County and Orange County connects to the beginning of the next section, at SR 528 (the Bee Line Expressway) east of Orlando International Airport. From there, SR 15 travels north on Narcoossee Road, west on Hoffner Road, north on Conway Road through Conway, west on Lake Underhill Road, and west on South Street (northbound) and Anderson Street (southbound) on both sides of SR 408 (the east–west Expressway) to downtown Orlando. It then travels north on Mills Avenue and continues all the way to downtown Jacksonville. From there it goes north along Main Street and west on the 20th Street Expressway, and then northwest into Georgia, as Georgia State Route 15.