Fludeoxyglucose (18F)

Fludeoxyglucose (18F)

Fludeoxyglucose (18F)

to get instant updates about 'Fludeoxyglucose (18F)' on your MyPage. Meet other similar minded people. Its Free!


All Updates

Fludeoxyglucose (<sup>18</sup>F) (INN) or fluorodeoxyglucose (<sup>18</sup>F), commonly abbreviated <sup>18</sup>F-FDG or FDG, is a radiopharmaceutical used in the medical imaging modality positron emission tomography (PET). Chemically, it is 2-deoxy-2-(<sup>18</sup>F)fluoro-D-glucose, a glucose analog, with the positron-emitting radioactive isotope fluorine-18 substituted for the normal hydroxyl group at the 2' position in the glucose molecule.

After <sup>18</sup>F-FDG is injected into a patient, a PET scanner can form images of the distribution of FDG around the body. The images can be assessed by a nuclear medicine physician or radiologist to provide diagnoses of various medical conditions.

Mechanism of action, metabolic end-products, and metabolic rate

FDG, as a glucose analog, is taken up by high-glucose-using cells such as brain, kidney, and cancer cells, where phosphorylation prevents the glucose from being released again from the cell, once it has been absorbed. The 2' hydroxyl group (—OH) in normal glucose is needed for further glycolysis (metabolism of glucose by splitting it), but FDG is missing this 2' hydroxyl. Thus, in common with its sister molecule 2-deoxy-<small>D</small>-glucose, FDG cannot be further metabolized in cells. The <sup>18</sup>F-FDG-6-phosphate formed when <sup>18</sup>F-FDG enters the cell thus cannot move out of the cell before radioactive...
Read More

No feeds found

Posting your question. Please wait!...

No updates available.
No messages found
Suggested Pages
Tell your friends >
about this page
 Create a new Page
for companies, colleges, celebrities or anything you like.Get updates on MyPage.
Create a new Page
 Find your friends
  Find friends on MyPage from