Father Ġorġ Preca first came to the attention of the Ordinary Congregation of the Cardinals and Bishops of the Congregation for Causes of Saints, which examined the scientifically unexplainable healing of Charles Zammit Endrich in 1964. Zammit Endrich had suffered from a detached retina of the left eye. The healing was declared as miraculous, and was attributed to the intercession of the Father Ġorġ Preca after Zammit Endrich prayed to him and placed one of the priest's belongings under his pillow. The healing took place outside of a hospital, overseen by the personal doctor of Zammit Endrich, Dr. Ċensu Tabone who was later to be appointed President of Malta.
On 24 June 1975, Archbishop Mikiel Gonzi issued a decree initiating the process of Preca's canonization. He was declared "venerable" on 28 June 1999, and on 27 January 2000, Pope John Paul II signed the decree which officially confirmed the Zammit Endrich healing.