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Glycogen synthase kinase 3 beta, also known as GSK3B, is an enzyme that in humans is encoded by the GSK3B gene.


Glycogen synthase kinase-3 (GSK-3) is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase. Two isoforms, alpha (GSK3A) and beta, show a high degree of amino acid homology.


GSK3B has been shown to interact with CTNNB1, SGK3, TSC2, AR, MUC1, AXIN1, PRKAR2A, AKAP11, DNM1L, P53, AXIN2, NOTCH2,<ref...
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