The homeostatic model assessment (HOMA) is a method used to quantify insulin resistance and beta-cell function. It was first described under the name HOMA by Matthews et al. in 1985.
The HOMA authors used data from physiological studies to develop mathematical equations describing glucose regulation as a feedback loop.
The computer model has since been improved to a HOMA2 model to better reflect human physiology and recalibrated to modern insulin assays. In this updated version it is possible to determine insulin sensitivity and β-cell function from paired fasting plasma glucose and Radioimmunoassay insulin, specific insulin, or C-peptide concentrations. The authors recommend the computer software be used wherever possible.
The HOMA model was originally designed as a special case of a more general model called HOMA-CIGMA.Turner et al. (1993) Measurement of insulin resistance and β-cell function:...... Read More