IL-2 receptor

to get instant updates about 'IL-2 Receptor' on your MyPage. Meet other similar minded people. Its Free!

X 

All Updates


Description:
The interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to a cytokine called IL-2. Three protein chains (α, β and γ) are non-covalently associated to form the IL-2R. The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ-chain, along with the β subunit. The β and γ chains of the IL-2R are members of the type I cytokine receptor family.

Discovery and characterization

The IL-2 receptor (IL-2R) was the first interleukin receptor to be described and characterized by Kendall Smith and his team at Dartmouth Medical School. It was found to have a high affinity binding site and is expressed by antigen-activated T lymphocytes (T cells). Radiolabeled IL-2 concentrations found to saturate these sites (e.g. 1-100 pM) were identical to those determined to promote T cell proliferation. Subsequently, the three distinct receptor chains, termed alpha (α), beta (β) and gamma (γ) were identified. The high affinity of IL-2 binding is created by a rapid association rate (k =...
Read More

No feeds found

All
Posting your question. Please wait!...


No updates available.
No messages found
Suggested Pages
Tell your friends >
about this page
 Create a new Page
for companies, colleges, celebrities or anything you like.Get updates on MyPage.
Create a new Page
 Find your friends
  Find friends on MyPage from