Mark joined the Manhattan Project in 1945, and continued to work at Los Alamos after World War II had ended. He became the leader of the Theoretical Division at the laboratory in 1947 under the lab directorship of Norris Bradbury (a position he held until 1973), and oversaw the development of the hydrogen bomb in the 1950s (see Teller-Ulam design for more on the development history).
Mark became a U.S. citizen in the 1950s and died in Los Alamos, New Mexico in 1997 from complications related to a fall.