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JLF Primary Materials, formerly known as JLF Poisonous Non Consumables, was a popular internet website during the last part of the 20th century which sold "research chemicals" — essentially new hallucinogenic, stimulant, and other drug analogues which had not as yet been made illegal. In addition, it sold a large variety of plants, as well as Amanita muscaria mushrooms. Critics say that most of the plants were a red herring designed to distract authorities from the real business of selling research chemicals.

The name "JLF Poisonous Non Consumables" was explained as describing how the owner completely discouraged any consumption of what he was selling. A famous interview occurred with the owner where he claimed that he had no idea that any of what he sold was psychoactive or analogous to illegal drugs. Nevertheless, the DEA raided JLF and caused it to cease selling research chemicals. This wasn't due however to the fact that JLF was selling analogues of then illegal drugs, but rather it was a part of a larger Food and Drug Administration (FDA) crackdown against a large group of herbal medicine providers.

The DEA has since arrested the owners of five sites selling research chemicals in what was named Operation Web Tryp. These include April Curtis, owner of RAC Research; Mike Burton, owner of American Chemical Supply; and the owners of Omega Fine Chemicals, Duncan Labs and LTK Research.

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