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Potassium voltage-gated channel, shaker-related subfamily, member 5, also known as KCNA5 or K<sub>v</sub>1.5 is a protein which in humans is encoded by the KCNA5 gene.


Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. KCNA5 encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12.. Mutations in this gene has been related to both atrial fibrillation .


KCNA5 has been shown to interact with DLG4 and Actinin, alpha 2.

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