Little Dry Creek is a short tributary of the South Platte River, approximately long, in Arapahoe County, Colorado in the United States. The creek drains a suburban area south of Denver. It rises in Centennial, west of , and flows generally northwest into Englewood. It has historically been used for irrigation and feeds an aqueduct that runs parallel to it. The creek no longer reaches South Platte above ground. The former mouth of the creek is located just northwest of the junction of and , across from the former site of the Cinderella City Mall.
The Little Dry Creek Trail intersects the Highline Canal Trail in Cherry Hills Village.
The mouth of the creek is noted as the location of the first significant gold discovery in present-day Colorado. In the first week of July 1858, Green Russell and his brothers discovered a gold pocket yielded several hundred dollars worth of gold. The discovery set off the Colorado Gold Rush in the following year.