LRP2

to get instant updates about 'LRP2' on your MyPage. Meet other similar minded people. Its Free!

X 

All Updates


Description:
Low density lipoprotein-related protein 2 also known as LRP2 or megalin is a protein which in humans is encoded by the LRP2 gene.

Function

LRP2 is a multiligand binding receptor found in the plasma membrane of many absorptive epithelial cell. LRP2 is a member of a family of receptors with structural similarities to the low density lipoprotein receptor (LDLR). LRP2 functions to mediate endocytosis of ligands leading to degradation in lysosomes or transcytosis. LRP2 (previously called glycoprotein 330) together with RAP (LRPAP1) forms the Heymann nephritis antigenic complex. LRP2 is expressed in epithelial cells of the thyroid (thyrocytes), where it can serve as a receptor for the protein thyroglobulin (Tg).

Clinical significance

Mutations in the LRP2 gene are associated with Donnai-Barrow syndrome.

Interactions

LRP2 has been shown to interact with LDL-receptor-related protein associated protein, LDLRAP1, MAPK8IP2, MAGI1,......
Read More

No feeds found

All
wait Posting your question. Please wait!...


No updates available.
No messages found
Suggested Pages
RRR
RRR
Tell your friends >
about this page
 Create a new Page
for companies, colleges, celebrities or anything you like.Get updates on MyPage.
Create a new Page
 Find your friends
  Find friends on MyPage from