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Low density lipoprotein-related protein 2 also known as LRP2 or megalin is a protein which in humans is encoded by the LRP2 gene.


LRP2 is a multiligand binding receptor found in the plasma membrane of many absorptive epithelial cell. LRP2 is a member of a family of receptors with structural similarities to the low density lipoprotein receptor (LDLR). LRP2 functions to mediate endocytosis of ligands leading to degradation in lysosomes or transcytosis. LRP2 (previously called glycoprotein 330) together with RAP (LRPAP1) forms the Heymann nephritis antigenic complex. LRP2 is expressed in epithelial cells of the thyroid (thyrocytes), where it can serve as a receptor for the protein thyroglobulin (Tg).

Clinical significance

Mutations in the LRP2 gene are associated with Donnai-Barrow syndrome.


LRP2 has been shown to interact with LDL-receptor-related protein associated protein, LDLRAP1, MAPK8IP2, MAGI1,......
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