On November 6, 2006, Gicquel broke into the top 50 after reaching his first ATP Tour final in Lyon, where he was defeated by Richard Gasquet, his countryman. On April 30, 2007, Gicquel broke into the top 40 after reaching the semifinals of Casablanca.
In a match during the 2007 Halle, Germany tournament, Gicquel was struck directly in the genitals by a 129 mph Benjamin Becker serve. He went on to beat Becker, but spent most of the night vomiting and in pain due to swelling and was forced to retire in his next match versus Jarkko Nieminen.