From 23 August 1944 to 18 March 1975 the minister held the title of Minister of Internal Affairs, between 2004 and 2007, held the title of Minister of Administration and Interior, and since April 2007, Minister of Interior and Administrative Reform. In December 2008, the Boc government changed the name back to Ministry of Administration and Interior.
Until 2006, the ministry was housed near Lipscani in Palatul Vama Poştei, built between 1914 and 1926 according to the architect Statie Ciortan's plans. In 2006 the ministry moved into the former building of the Senate in the Revolution Square. This was the same building from which Nicolae Ceaușescu tried to make his last speech, and from its roof he fled by helicopter the next day.