MRNA (guanine-N7-)-methyltransferase

MRNA (Guanine-N7-)-Methyltransferase

MRNA (guanine-N7-)-methyltransferase

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Description:
In enzymology, a mRNA (guanine-N7-)-methyltransferase () is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + G(5')pppR-RNA <math>rightleftharpoons</math> S-adenosyl-L-homocysteine + m<sub>7</sub>G(5')pppR-RNA (mRNA containing an N<sub>7</sub>-methylguanine cap)


Thus, the two substrates of this enzyme are S-adenosyl methionine and GpppR-RNA, whereas its two products are S-adenosylhomocysteine and m7GpppR-RNA.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase. Other names in common use include messenger ribonucleate guanine 7-methyltransferase, guanine-7-methyltransferase, messenger RNA guanine 7-methyltransferase, and S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .

References








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