MRNA (nucleoside-2'-O-)-methyltransferase

MRNA (Nucleoside-2'-O-)-Methyltransferase

MRNA (nucleoside-2'-O-)-methyltransferase

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In enzymology, a mRNA (nucleoside-2'-O-)-methyltransferase () is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + m<sub>7</sub>G(5')pppR-RNA <math>rightleftharpoons</math> S-adenosyl-L-homocysteine + m<sub>7</sub>G(5')pppRm-RNA (mRNA containing a 2'-O-methylpurine cap)

Thus, the two substrates of this enzyme are S-adenosyl methionine and m7GpppR-RNA, whereas its two products are S-adenosylhomocysteine and m7GpppRm-RNA .

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase. Other names in common use include messenger ribonucleate nucleoside 2'-methyltransferase, and messenger RNA (nucleoside-2'-)-methyltransferase.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .


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