Neuropeptide Y receptor

Neuropeptide Y Receptor

Neuropeptide Y receptor

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Neuropeptide Y receptors are a class of G-protein coupled receptors which are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide. These receptors are involved in control of a diverse set of behavioral processes including appetite, circadian rhythm, and anxiety.

Activated neuropeptide receptors release the G<sub>i</sub> subunit from the heterotrimeric G protein complex. The G<sub>i</sub> subunit in turn inhibits the production of the second messenger cAMP from ATP.


There are five known mammalian neuropeptide Y receptors designated Y<sub>1</sub> through Y<sub>5</sub>.
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