Nucleoside deoxyribosyltransferase

In enzymology, a nucleoside deoxyribosyltransferase () is an enzyme that catalyzes the chemical reaction

2-deoxy-D-ribosyl-base₁ + base₂ <math>rightleftharpoons</math> 2-deoxy-D-ribosyl-base₂ + base₁

Thus, the two substrates of this enzyme are 2-deoxy-D-ribosyl-base₁ and base₂, whereas its two products are 2-deoxy-D-ribosyl-base₂ and base₁.

This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is nucleoside:purine(pyrimidine) deoxy-D-ribosyltransferase. Other names in common use include purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyl, transferase, deoxyribose transferase, nucleoside trans-N-deoxyribosylase, trans-deoxyribosylase, trans-N-deoxyribosylase, trans-N-glycosidase, nucleoside deoxyribosyltransferase I (purine nucleoside:purine, deoxyribosyltransferase: strictly specific for transfer between, purine bases), nucleoside deoxyribosyltransferase II . This enzyme participates in pyrimidine metabolism.

Structural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , , , , , and .

References

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