"The best actor I ever worked with was Osgood Perkins," Louise Brooks told Kevin Brownlow. "You know what makes an actor great to work with? Timing. You don't have to feel anything. It's like dancing with a perfect dancing partner. Osgood Perkins would give you a line so that you would react perfectly. It was timing -- because emotion means nothing." Brooks and Perkins appeared together in Love 'Em and Leave 'Em (1926).
Perkins married Janet Esselstyn Rane, in 1922. They had one child, actor Anthony Perkins. Osgood died of a heart attack in Washington, D.C., at age 45. Anthony was just five-years-old at the time.