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In the field of molecular biology, the P2Y<sub>12</sub> protein is found mainly but not only on the surface of blood platelet cells and is an important regulator in blood clotting.

P2Y<sub>12</sub> belongs to the Gi class of a group of G protein-coupled (GPCR) purinergic receptors and is a chemoreceptor for adenosine diphosphate (ADP). The P2Y family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolism and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene.

Clinical significance

The drug clopidogrel (Plavix) binds to this receptor and is marketed as an antiplatelet.


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