P300-CBP coactivator family

P300-CBP Coactivator Family

P300-CBP coactivator family

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The p300-CBP coactivator family is composed of two closely related transcriptional co-activating proteins (or coactivators):

  1. p300 (also called EP300 or E1A binding protein p300)
  2. CBP (also known as CREB-binding protein or CREBBP)

Both p300 and CBP interact with numerous transcription factors and act to increase the expression of their target genes.

Protein structure

p300 and CBP have similar structures. Both contain five protein interaction domains: the nuclear receptor interaction domain (RID), the CREB and MYB interaction domain (KIX), the cysteine/histidine regions (CH1 and CH3) and the interferon response binding domain (IBiD). In addition p300 and CBP each contain a protein or histone acetyltransferase (PAT/HAT) domain and a bromodomain that binds acetylated lysines and a PHD finger motif with unknown function. The conserved domains are connected by long stretches of unstructured linkers.

Regulation of gene expression

p300 and CBP are thought to increase gene expression in three ways:

  1. by relaxing the chromatin structure at the gene promoter through their intrinsic histone acetyltransferase (HAT) activity.
  2. recruiting the basal transcriptional machinery including RNA polymerase II to the promoter.
  3. acting as adaptor molecules.

Function in G......

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