Plasma membrane Ca2+ ATPase

Plasma Membrane Ca2+ ATPase

Plasma membrane Ca2+ ATPase

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The plasma membrane Ca<sup>2+</sup> ATPase (PMCA) is a transport protein in the plasma membrane of cell that serves to remove calcium (Ca<sup>2+</sup>) from the cell. It is vital for regulating the amount of Ca<sup>2+</sup> within cells. from all eukaryotic cells.There is a very large transmembrane electrochemical gradient of Ca<sup>2+</sup> driving the entry of the ion into cells, yet it is very important for cells to maintain low concentrations of Ca<sup>2+</sup> for proper cell signalling; thus it is necessary for the cell to employ ion pump to remove the Ca<sup>2+</sup>.The PMCA and the sodium calcium exchanger (NCX) are together the main regulators of intracellular Ca<sup>2+</sup> concentrations. into the extracellular space, the PMCA is also an important regulator of the calcium concentration in the extracellular space.

The PMCA belongs to a family of P-type primary ion transport ATPases that form an aspartyl phosphate intermediate.

The PMCA is expressed in a variety of tissue, including the brain.<ref...
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