The community was the subject of an American raid during the War of 1812, on May 14, 1814.In 1835, Port Dover was incorporated as a village and later as a town. In 1974, the town was amalgamated into the new city of Nanticoke within the Regional Municipality of Haldimand-Norfolk. In 2001, Nanticoke and all other municipalities within the region were dissolved and the region was divided into two single tier municipalities with city-status but called counties. Port Dover is now an unincorporated community in Ward 6 of Norfolk County.