It descends on the interosseous membrane, in front of the Extensor pollicis longus, to the back of the carpus, where it presents a gangliform enlargement from which filaments are distributed to the ligaments and articulations of the carpus.
The posterior interosseous nerve may be entrapped at the Arcade of Frohse, which is part of the Supinator muscle. Posterior interosseous neuropathy is purely a motor syndrome resulting in finger drop, and radial wrist deviation on extension.