RAS p21 protein activator 1

RAS P21 Protein Activator 1

RAS p21 protein activator 1

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RAS p21 protein activator 1 or RasGAP (Ras GTPase activating protein), also known as RASA1, is a 120-kDa cytosolic human protein that provides two principal activities:
  • Inactivation of Ras from its active GTP-bound form to its unactive GDP-bound form by enhancing the endogenous GTPase activity of Ras, via its C-terminal GAP domain
  • Mitogenic signal transmission towards downstream interacting partners through its N-terminal SH2-SH3-SH2 domains

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RasGAP contains one SH3 domain and two SH2 domains, a PH domain, and a GAP domain.


RAS p21 protein activator 1 has been shown to interact with SOCS3, ANXA6, Huntingtin, KHDRBS1, Src, EPHB3, EPH receptor B2, Insulin-like growth factor 1 receptor, PTK2B, DOK1,<ref...
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