Rous sarcoma virus

Rous Sarcoma Virus

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Rous sarcoma virus

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Description:
Rous sarcoma virus is a retrovirus and is the first oncovirus to have been described: it causes sarcoma in chickens.

As with all retroviruses, it reverse transcribes its RNA genome into cDNA before integration into the host DNA.

History

RSV was discovered in 1911 by Peyton Rous, working at Rockefeller University in New York City, by injecting cell free extract of chicken tumour into healthy Plymouth Rock chickens.The extract was found to induce oncogenesis. The tumour was found to be composed of connective tissue (a sarcoma).

Rous was awarded the Nobel Prize for the significance of his discovery in 1966.

Structure and genome



RSV is a class VI enveloped virus with a positive sense RNA genome having a DNA intermediate.

RSV has three genes:
  • gag - encodes capsid proteins
  • pol - encodes reverse transcriptase


(It lost the env gene normally seen in avian retroviruses during the recombination events that allowed it to acquire src)



The RSV genome has terminal repeats enabling its integration into the host genome and also overexpression of RSV genes.

src gene

The src gene is oncogenic as it triggers uncontrolled growth in abnormal host cells. It is an acquired gene, found to be present throughout the animal kingdom with high levels of conservation between species.

The src gene was taken up by RSV and incorporated into its genome conferring it with the advantage of...
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