The Royal Scots College was founded at Madrid in 1627 by Colonel William Semple of Lochwinnoch and his wife, Doña María de Ledesma. Semple had spent his life in the military and diplomatic service of the Spanish crown.
The deed of foundation stipulated that the college was for students "Scottish by birth, preferably those of superior character and virtue and those who promise more fruit in the welfare of souls, and they have to spend whatever time may be necessary in studying Grammar and Philosophy, Theology, Controversies and Sacred Scripture, so that when they are well versed in all of these, they may proceed to the said Kingdom of Scotland to preach the Gospel and convert heretics... when they leave the said seminary for this purpose, others are to be received in their place having the same end, and thus the matter will continue for as long as the aforesaid conversion may require."
The ScottishJesuitHugh Semple was procurator of the Scots College when it was located in Madrid. In 1771, it was transferred to Valladolid. The College was transferred to Salamanca in 1988.