On April 5, 1925, he responded to an advertisement offering a flying boat for sale in Portland, Oregon, where he lived at the time. This started his career as a bush pilot, and on May 26, 1925 he arrived at Ketchikan, Alaska.
Merrill was the first to fly to many cities in Alaska; the first airport in Anchorage was named Merrill Field in his honor. On September 16, 1929, Merrill departed on a flight from Anchorage to the Nyac mine near Bethel, and was never seen again.