The city was founded in 1827 on the location of a ranch. Arrival of the railroad accelerated its developmentSan Luis achieved municipality status on 19 August 1898.
Demographics
In 2004, the municipality of San Luis had a population of 88,496. With a total area of , it has a population density of .
The municipality is divided into the barrios of Dos Caminos, La Luz, Majaguabo, Monte Dos Leguas, Norte and Sur.